1. Risk Stratification, Precision Diagnostics and Clinical Decision Modelling
To improve pre-intervention clinical decision-making through predictive models, biomarkers, artificial intelligence and real-world data.
1.1 Personalised screening and population implementation
- Risk-adapted screening (prostate, CRC)
- Primary care-hospital integration
- Risk-based public health models
1.2 Molecular biomarkers and precision diagnostics
- Faecal microRNAs
- ctDNA and circulating biomarkers
- Clinical genomics integration
1.3 Predictive modelling and clinical decision support
- Clinical-molecular multivariable models
- AI-based diagnostic prioritisation
- Prospective validation and healthcare impact
1.4 Registry-based and real-world data research
- Large cohort analysis
- OMOP harmonisation
- Guideline and consensus development
2. Minimally Invasive and Advanced Surgical-Endoscopic Innovation
To optimise surgical and endoscopic treatments through technological innovation, international benchmarking and reduction of clinical variability.
2.1 Minimally invasive and robotic colorectal surgery
- Oncological outcomes
- European benchmarking
- Perioperative optimisation
2.2 Device innovation and biomedical engineering
- Personalised 3D printing
- Surgical material development
- Industrial transfer and MDR regulation
2.3 Advanced endoscopy and procedural quality
- Optical diagnosis
- AI-assisted adenoma detection
- Standardisation and variability reduction
2.4 Peri-interventional optimisation
- Pharmacological management
- Safety protocols
- Bowel preparation strategies
3. Functional Outcomes, Survivorship and Translational Care Innovation
To improve quality of life, functional outcomes and biomarker-based monitoring after intervention.
3.1 Post-surgical functional outcomes
- Anorectal function
- Urinay dysfunction
- Pelvic rehabilitation
3.2 Device innovation for quality of life
- Non-invasive devices
- Development and patenting
- Clinical validation
3.3 Biomarkers in monitoring and recurrence
- Personalised ctDNA
- Predictive toxicity biomarkers
- Translational monitoring
3.4 Survivorship and structured care models
- Integrated PROMS
- Multidisciplinary follow-up
- Implementation in clinical pathways